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Hyperammonemia Associated with Valproic Acid Concentrations
Joint Authors
Maldonado, Cecilia
Fagiolino, Pietro
Olano, Ivette
Ibarra, Manuel
Vázquez, Marta
Guevara, Natalia
Alvariza, Silvana
Olmos, Ismael
Magallanes, Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder.
It is extensively metabolized in liver, representing β-oxidation in the mitochondria one of its main metabolic route (40%).
Carnitine is responsible for its entry into the mitochondria as any other fatty acid.
Long-term high-dose VPA therapy or acute VPA overdose induces carnitine depletion, resulting in high levels of ammonia in blood.
As a high correlation between salivary valproic acid levels and plasma ultrafiltrate levels was found in humans, saliva becomes a promising monitoring fluid in order to study valproic acid pharmacokinetics and its toxic effect.
Extended-release (twice daily) formulations of valproic acid or carnitine supplementation are the proposed two therapeutic strategies in order to reverse hyperammonemia.
American Psychological Association (APA)
Vázquez, Marta& Fagiolino, Pietro& Maldonado, Cecilia& Olmos, Ismael& Ibarra, Manuel& Alvariza, Silvana…[et al.]. 2014. Hyperammonemia Associated with Valproic Acid Concentrations. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-455377
Modern Language Association (MLA)
Vázquez, Marta…[et al.]. Hyperammonemia Associated with Valproic Acid Concentrations. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-455377
American Medical Association (AMA)
Vázquez, Marta& Fagiolino, Pietro& Maldonado, Cecilia& Olmos, Ismael& Ibarra, Manuel& Alvariza, Silvana…[et al.]. Hyperammonemia Associated with Valproic Acid Concentrations. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-455377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455377