Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction
Joint Authors
Tsai, Wei-Chuan
Chang, Yu-Tzu
Sung, Junne-Ming
Chen, Jyh-Hong
Tsai, Liang-Miin
Yang, Chun-Shin
Liu, Yen-Wen
Su, Yu-Ru
Su, Chi-Ting
Wang, Saprina P. H.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Using a speckle-tracking echocardiography (STE), we recently demonstrated that a left ventricular (LV) global longitudinal strain (GLS) ≥ −15% and the serum cardiac troponin T (cTnT) concentration are associated with mortality in stable hemodialysis patients with preserved LV ejection fraction (LVEF).
In this study, we explored the relationship between cTnT and echocardiographic parameters and evaluated whether the prognostic value provided by cTnT is independent of a GLS ≥ −15% and vice versa.
Eighty-eight stable hemodialysis patients with preserved LVEF were followed for 31 months.
STE studies and measurements of cTnT were performed at baseline.
CTnT concentration had a modest correlation with GLS (rs=0.44; P<0.001) but had a weak or nonsignificant correlation with other echocardiographic parameters.
Adjusting for clinical parameters, hazard ratios for each increase of 0.01 ng/mL in cTnT, and a GLS ≥ −15% on mortality were 1.13 (P=0.009) and 3.09 (P=0.03) without significant interaction between cTnT and GLS ≥ −15%.
In addition, an increased cTnT concentration, a GLS ≥ −15%, or their combination showed significant additional predictive value for mortality when included in models consisting of clinical parameters.
Therefore, both cTnT and a GLS ≥ −15% are independent predictors of mortality and are useful for risk stratification.
American Psychological Association (APA)
Sung, Junne-Ming& Su, Chi-Ting& Chang, Yu-Tzu& Su, Yu-Ru& Tsai, Wei-Chuan& Wang, Saprina P. H.…[et al.]. 2014. Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455381
Modern Language Association (MLA)
Sung, Junne-Ming…[et al.]. Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-455381
American Medical Association (AMA)
Sung, Junne-Ming& Su, Chi-Ting& Chang, Yu-Tzu& Su, Yu-Ru& Tsai, Wei-Chuan& Wang, Saprina P. H.…[et al.]. Independent Value of Cardiac Troponin T and Left Ventricular Global Longitudinal Strain in Predicting All-Cause Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455381