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Basal Cell Carcinomas in Gorlin Syndrome : A Review of 202 Patients
Joint Authors
Shenton, Andrew
Evans, D. Gareth
Sajid, Mohammed Imran
Jones, Elizabeth A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gorlin syndrome (Naevoid Basal Cell Carcinoma Syndrome) is a rare autosomal dominant syndrome caused by mutations in the PTCH gene with a birth incidence of approximately 1 in 19,000.
Patients develop multiple basal cell carcinomas of the skin frequently in early life and also have a predisposition to additional malignancies such as medulloblastoma.
Gorlin Syndrome patients also have developmental defects such as bifid ribs and other complications such as jaw keratocysts.
We studied the incidence and frequency of basal cell carcinomas in 202 Gorlin syndrome patients from 62 families and compared this to their gender and mutation type.
Our data suggests that the incidence of basal cell carcinomas is equal between males and females and the mutation type cannot be used to predict disease burden.
American Psychological Association (APA)
Jones, Elizabeth A.& Sajid, Mohammed Imran& Shenton, Andrew& Evans, D. Gareth. 2010. Basal Cell Carcinomas in Gorlin Syndrome : A Review of 202 Patients. Journal of Skin Cancer،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455393
Modern Language Association (MLA)
Jones, Elizabeth A.…[et al.]. Basal Cell Carcinomas in Gorlin Syndrome : A Review of 202 Patients. Journal of Skin Cancer No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-455393
American Medical Association (AMA)
Jones, Elizabeth A.& Sajid, Mohammed Imran& Shenton, Andrew& Evans, D. Gareth. Basal Cell Carcinomas in Gorlin Syndrome : A Review of 202 Patients. Journal of Skin Cancer. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455393