The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies
Joint Authors
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Loss of visual function differs between immune-mediated optic neuropathies and is related to axonal loss in the optic nerve.
This study investigated the diagnostic and prognostic value of a biomarker for neurodegeneration, the neurofilament heavy chain (NfH) in three immune-mediated optic neuropathies.
Methods.
A prospective, longitudinal study including patients with optic neuritis due to multiple sclerosis (MSON, n=20), chronic relapsing inflammatory optic neuritis (CRION, n=19), neuromyelitis optica (NMO, n=9), and healthy controls (n=28).
Serum NfH-SMI35 levels were quantified by ELISA.
Findings.
Serum NfH-SMI35 levels were highest in patients with NMO (mean 0.79±1.51 ng/mL) compared to patients with CRION (0.13±0.16 ng/mL, P=0.007), MSON (0.09±0.09, P=0.008), and healthy controls (0.01±0.02 ng/mL, P=0.001).
High serum NfH-SMI35 levels were related to poor visual outcome.
Conclusions.
Blood NfH-SMI35 levels are of moderate diagnostic and more important prognostic value in immune-mediated optic neuropathies.
We speculate that longitudinal blood NfH levels may help to identify particular disabling events in relapsing conditions.
American Psychological Association (APA)
Petzold, Axel& Plant, Gordon T.. 2012. The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-455428
Modern Language Association (MLA)
Petzold, Axel& Plant, Gordon T.. The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies. Multiple Sclerosis International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-455428
American Medical Association (AMA)
Petzold, Axel& Plant, Gordon T.. The Diagnostic and Prognostic Value of Neurofilament Heavy Chain Levels in Immune-Mediated Optic Neuropathies. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-455428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455428