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Novel Antidepressant-Like Activity of Propolis Extract Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus
Joint Authors
Shim, Insop
Morita, Kyoji
Ahn, Won Gyeong
Her, Song
Lee, Mi-Sook
Kwon, Seung-Hae
Kim, Young Han
Park, Wan-Soon
Park, Ok Kyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Propolis is a natural product made by honeybees that has been widely used in folk medicine with a broad spectrum of biological activities.
To investigate the antidepressant-like activity of propolis extract, CD-1 mice were administered an ethanol extract of propolis (50, 100, or 200 mg/kg, p.o.) prior to the behavioral test.
The propolis extract-treated group showed a dose-dependent decrease in immobility time in the FST and tail suspension test without altering locomotor activity.
Propolis extract decreased the limbic hypothalamic-pituitary-adrenal axis response to the FST as indicated by an attenuated corticosterone response and decreased in c-fos immunoreactive neurons in the hippocampal dentate gyrus.
Western blot analysis revealed a reduction in hippocampal glucocorticoid receptor (GR) expression following the FST, which was reversed by propolis extract.
Propolis extract also increased pGR(S220)/(S234) ratio by a differential phosphorylation in S220 and S234.
FST-induced downregulation of cAMP-responsive element binding protein phosphorylation at S133 (pCREB) was restored by propolis extract, showing a strong and positive relationship between pCREB and pGR(S220)/(S234) ratio.
These findings suggest that the propolis extract potentiates antidepressant-like activity by enhancing GR function which is one of the therapeutic mechanisms of antidepressant; thus, propolis extract may provide a novel therapy for depression.
American Psychological Association (APA)
Lee, Mi-Sook& Kim, Young Han& Park, Wan-Soon& Ahn, Won Gyeong& Park, Ok Kyu& Kwon, Seung-Hae…[et al.]. 2013. Novel Antidepressant-Like Activity of Propolis Extract Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-455433
Modern Language Association (MLA)
Lee, Mi-Sook…[et al.]. Novel Antidepressant-Like Activity of Propolis Extract Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-455433
American Medical Association (AMA)
Lee, Mi-Sook& Kim, Young Han& Park, Wan-Soon& Ahn, Won Gyeong& Park, Ok Kyu& Kwon, Seung-Hae…[et al.]. Novel Antidepressant-Like Activity of Propolis Extract Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-455433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455433