Role of NHE1 in Nociception
Joint Authors
Guzmán-Priego, Crystell Guadalupe
Granados-Soto, Vinicio
Rocha-González, Héctor Isaac
Torres-López, Jorge Elías
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis.
In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage.
Mammalian Na+/H+ exchangers (NHEs) are electroneutral Na+-dependent proteins that exchange extracellular Na+ for intracellular H+.
To date, there are 9 identified NHE isoforms where NHE1 is the most ubiquitous member, known as the housekeeping exchanger.
NHE1 seems to have a protective role in the ischemia-reperfusion injury and other inflammatory diseases.
In nociception, NHE1 is found in neurons along nociceptive pathways, and its pharmacological inhibition increases nociceptive behavior in acute pain models at peripheral and central levels.
Electrophysiological studies also show that NHE modulates electrical activity of primary nociceptive terminals.
However, its role in neuropathic pain still remains controversial.
In humans, NHE1 may be responsible for inflammatory bowel diseases since its expression is reduced in Crohn’s disease and ulcerative colitis.
The purpose of this work is to provide a review of the evidence about participation of NHE1 in the nociceptive processing.
American Psychological Association (APA)
Torres-López, Jorge Elías& Guzmán-Priego, Crystell Guadalupe& Rocha-González, Héctor Isaac& Granados-Soto, Vinicio. 2013. Role of NHE1 in Nociception. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-455438
Modern Language Association (MLA)
Torres-López, Jorge Elías…[et al.]. Role of NHE1 in Nociception. Pain Research and Treatment No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-455438
American Medical Association (AMA)
Torres-López, Jorge Elías& Guzmán-Priego, Crystell Guadalupe& Rocha-González, Héctor Isaac& Granados-Soto, Vinicio. Role of NHE1 in Nociception. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-455438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455438