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Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an IschemiaReperfusion Model
Joint Authors
Francisco, Díaz-Cedillo
Marcela, Rosas-Nexticapa
Elodia, García-Cervera
Monica, Velázquez-Sarabia Betty
Eduardo, Pool-Gómez
Lenin, Hau-Heredia
Betty, Sarabia-Alcocer
Lauro, Figueroa-Valverde
Maria, López-Ramos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Some reports indicate that several steroid derivatives have activity at cardiovascular level; nevertheless, there is scarce information about the activity exerted by the testosterone derivatives on cardiac injury caused by ischemia/reperfusion (I/R).
Analyzing these data, in this study, a new testosterone derivative was synthetized with the objective of evaluating its effect on myocardial injury using an ischemia/reperfusion model.
In addition, perfusion pressure and coronary resistance were evaluated in isolated rat hearts using the Langendorff technique.
Additionally, molecular mechanism involved in the activity exerted by the testosterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in the absence or presence of the following compounds: flutamide, prazosin, metoprolol, nifedipine, indomethacin, and PINANE TXA2.
The results showed that the testosterone derivative significantly increases P=0.05 the perfusion pressure and coronary resistance in isolated heart.
Other data indicate that the testosterone derivative increases left ventricular pressure in a dose-dependent manner (0.001–100 nM); however, this phenomenon was significantly inhibited P=0.06 by indomethacin and PINANE-TXA2 P=0.05 at a dose of 1 nM.
In conclusion, these data suggest that testosterone derivative induces changes in the left ventricular pressure levels through thromboxane receptor activation.
American Psychological Association (APA)
Lauro, Figueroa-Valverde& Francisco, Díaz-Cedillo& Elodia, García-Cervera& Eduardo, Pool-Gómez& Maria, López-Ramos& Marcela, Rosas-Nexticapa…[et al.]. 2014. Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an IschemiaReperfusion Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455439
Modern Language Association (MLA)
Lauro, Figueroa-Valverde…[et al.]. Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an IschemiaReperfusion Model. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-455439
American Medical Association (AMA)
Lauro, Figueroa-Valverde& Francisco, Díaz-Cedillo& Elodia, García-Cervera& Eduardo, Pool-Gómez& Maria, López-Ramos& Marcela, Rosas-Nexticapa…[et al.]. Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an IschemiaReperfusion Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455439