Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury
Joint Authors
Vlaar, Alexander P. J.
Schultz, Marcus J.
Roelofs, Joris J. T. H.
Juffermans, Nicole P.
de Waard, Vivian
Hofstra, Jorrit-Jan H.
Wolthuis, Esther K.
Source
Critical Care Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ventilator-induced lung injury (VILI) is associated with inhibition of the fibrinolytic system secondary to increased production of plasminogen activator inhibitor- (PAI-)1.
To determine the role of PAI-1 on pulmonary coagulopathy and inflammation during mechanical ventilation, PAI-1 gene-deficient mice and their wild-type littermates were anesthetized (control), or anesthetized, tracheotomized and subsequently ventilated for 5 hours with either low tidal volumes (LVT) or high tidal volumes (HVT).
VILI was assessed by pulmonary coagulopathy, lung wet-to-dry ratios, total protein level in bronchoalveolar lavage fluid, neutrophil influx, histopathology, and pulmonary and plasma cytokine levels.
Ventilation resulted in pulmonary coagulopathy and inflammation, with more injury following ventilation with HVT as compared to LVT.
In PAI-1 gene-deficient mice, the influx of neutrophils in the pulmonary compartment was attenuated, while increased levels of pulmonary cytokines were found.
Other endpoints of VILI were not different between PAI-1 gene-deficient and wild-type mice.
These data indicate that a defect fibrinolytic response attenuates recruitment of neutrophils in VILI.
American Psychological Association (APA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Hofstra, Jorrit-Jan H.& Roelofs, Joris J. T. H.& de Waard, Vivian& Juffermans, Nicole P.…[et al.]. 2011. Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury. Critical Care Research and Practice،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455443
Modern Language Association (MLA)
Wolthuis, Esther K.…[et al.]. Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury. Critical Care Research and Practice No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-455443
American Medical Association (AMA)
Wolthuis, Esther K.& Vlaar, Alexander P. J.& Hofstra, Jorrit-Jan H.& Roelofs, Joris J. T. H.& de Waard, Vivian& Juffermans, Nicole P.…[et al.]. Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury. Critical Care Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455443