Ghrelin O-Acyl Transferase : Bridging Ghrelin and Energy Homeostasis
Joint Authors
Shlimun, Andrew
Unniappan, Suraj
Source
International Journal of Peptides
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ghrelin O-acyl transferase (GOAT) is a recently identified enzyme responsible for the unique n-acyl modification of ghrelin, a multifunctional metabolic hormone.
GOAT structure and activity appears to be conserved from fish to man.
Since the acyl modification is critical for most of the biological actions of ghrelin, especially metabolic functions, GOAT emerged as a very important molecule of interest.
The research on GOAT is on the rise, and several important results reiterating its significance have been reported.
Notable among these discoveries are the identification of GOAT tissue expression patterns, effects on insulin secretion, blood glucose levels, feeding, body weight, and metabolism.
Several attempts have been made to design and test synthetic compounds that can modulate endogenous GOAT, which could turn beneficial in favorably regulating whole body energy homeostasis.
This paper will focus to provide an update on recent advances in GOAT research and its broader implications in the regulation of energy balance.
American Psychological Association (APA)
Shlimun, Andrew& Unniappan, Suraj. 2011. Ghrelin O-Acyl Transferase : Bridging Ghrelin and Energy Homeostasis. International Journal of Peptides،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455452
Modern Language Association (MLA)
Shlimun, Andrew& Unniappan, Suraj. Ghrelin O-Acyl Transferase : Bridging Ghrelin and Energy Homeostasis. International Journal of Peptides No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-455452
American Medical Association (AMA)
Shlimun, Andrew& Unniappan, Suraj. Ghrelin O-Acyl Transferase : Bridging Ghrelin and Energy Homeostasis. International Journal of Peptides. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455452