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The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration
Joint Authors
Villanueva, I.
Pacheco-Rosado, J.
Alva-Sánchez, C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Reactive oxygen species (ROS) are oxidizing agents amply implicated in tissue damage.
ROS production is inevitably linked to ATP synthesis in most cells, and the rate of production is related to the rate of cell respiration.
Multiple antioxidant mechanisms limit ROS dispersion and interaction with cell components, but, when the balance between ROS production and scavenging is lost, oxidative damage develops.
Many traits of aging are related to oxidative damage by ROS, including neurodegenerative diseases.
Thyroid hormones (THs) are a major factor controlling metabolic and respiratory rates in virtually all cell types in mammals.
The general metabolic effect of THs is a relative acceleration of the basal metabolism that includes an increase of the rate of both catabolic and anabolic reactions.
THs are related to oxidative stress not only by their stimulation of metabolism but also by their effects on antioxidant mechanisms.
Thyroid dysfunction increases with age, so changes in THs levels in the elderly could be a factor affecting the development of neurodegenerative diseases.
However, the relationship is not always clear.
In this review, we analyze the participation of thyroid hormones on ROS production and oxidative stress, and the way the changes in thyroid status in aging are involved in neurodegenerative diseases.
American Psychological Association (APA)
Villanueva, I.& Alva-Sánchez, C.& Pacheco-Rosado, J.. 2013. The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-455469
Modern Language Association (MLA)
Villanueva, I.…[et al.]. The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-455469
American Medical Association (AMA)
Villanueva, I.& Alva-Sánchez, C.& Pacheco-Rosado, J.. The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-455469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455469