![](/images/graphics-bg.png)
MicroRNAs-Role in Lung Cancer
Joint Authors
Polberg, Krzysztof
Słomka, Maria
Stepulak, Andrzej
Guz, Małgorzata
Stenzel-Bembenek, Agnieszka
Okoń, Estera
Rivero-Müller, Adolfo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Regulation of gene expression is essential for normal physiological functions; thus deregulation of gene expression is common in disease conditions.
One level of regulation of gene expression is performed by noncoding RNAs, among which microRNAs (miRNA) are the best studied.
Abnormal expression of these molecular players can lead to pathogenic processes such as heart disease, immune system abnormalities, and carcinogenesis, to name but a few.
Of a length of 18–25 nucleotides miRNAs are involved in binding partial complementary sequences within the 3′-UTR (3′-untranslated region) of the target mRNAs.
Depending on the type of neoplastic transformation, miRNAs can act both as oncogenes (oncomirs) or as tumor suppressors.
Because of the great importance of miRNAs, most researches focus on either their role as biomarkers or their potential as therapeutic targets.
Herein, we present the review of microRNA biology, function, and tumorigenic potential with emphasis on their role in lung cancer.
American Psychological Association (APA)
Guz, Małgorzata& Rivero-Müller, Adolfo& Okoń, Estera& Stenzel-Bembenek, Agnieszka& Polberg, Krzysztof& Słomka, Maria…[et al.]. 2014. MicroRNAs-Role in Lung Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-455472
Modern Language Association (MLA)
Guz, Małgorzata…[et al.]. MicroRNAs-Role in Lung Cancer. Disease Markers No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-455472
American Medical Association (AMA)
Guz, Małgorzata& Rivero-Müller, Adolfo& Okoń, Estera& Stenzel-Bembenek, Agnieszka& Polberg, Krzysztof& Słomka, Maria…[et al.]. MicroRNAs-Role in Lung Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-455472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455472