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Effects of Proton Pump Inhibitors and H2 Receptor Antagonists on the Ileum Motility
Joint Authors
Aydın, Cengiz
Kaya, Tijen
Topcu, Omer
Kurt, Atilla
Altun, Ahmet
Bağcivan, İhsan
Koyuncu, Ayhan
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To investigate the effects of proton pump inhibitors (PPIs) and H2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats.
Methods.
Peritonitis was induced by cecal ligation and puncture in 8 rats.
Another of 8 rats underwent a sham operation and were accepted as controls.
Twenty-four hours later after the operation, the rats were killed, and their ileum smooth muscle was excised and placed in circular muscle direction in a 10 mL organ bath.
Changes in amplitude and frequency of contractions were analyzed before and after PPIs and H2 receptor blockers.
Results.
PPI agents decreased the motility in a dose-dependent manner in ileum in both control and intraabdominal sepsis groups.
While famotidine had no significant effect on ileum motility, ranitidine and nizatidine enhanced motility in ileum in both control and intraabdominal sepsis groups.
This excitatory effect of H2 receptor antagonists and inhibitor effects of PPIs were significantly high in control group when compared to the peritonitis group.
The inhibitor effect of pantoprazole on ileum motility was significantly higher than the other two PPI agents.
Conclusions.
It was concluded that H2 receptor antagonists may be more effective than PPIs for recovering the bowel motility in the intraabdominal sepsis situation.
American Psychological Association (APA)
Kurt, Atilla& Altun, Ahmet& Bağcivan, İhsan& Koyuncu, Ayhan& Topcu, Omer& Aydın, Cengiz…[et al.]. 2011. Effects of Proton Pump Inhibitors and H2 Receptor Antagonists on the Ileum Motility. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455483
Modern Language Association (MLA)
Kurt, Atilla…[et al.]. Effects of Proton Pump Inhibitors and H2 Receptor Antagonists on the Ileum Motility. Gastroenterology Research and Practice No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-455483
American Medical Association (AMA)
Kurt, Atilla& Altun, Ahmet& Bağcivan, İhsan& Koyuncu, Ayhan& Topcu, Omer& Aydın, Cengiz…[et al.]. Effects of Proton Pump Inhibitors and H2 Receptor Antagonists on the Ileum Motility. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455483