Early Monitoring Antiangiogenesis Treatment Response of Sunitinib in U87MG Tumor Xenograft by 18F-FLT MicroPETCT Imaging
Joint Authors
Wang, Ming-Wei
Bao, Xiao
Zhang, Yong-Ping
Zhang, Ying-Jian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
It was aimed to monitor early treatment response of Sunitinib in U87MG models mimicking glioblastoma multiforme by longitudinal 18F-FLT microPET/CT imaging in this study.
Methods.
U87MG tumor mice were intragastrically injected with Sunitinib at a dose of 80 mg/kg for consecutive 7 days.
18F-FLT microPET/CT scans were acquired on days 0, 1, 3, 7, and 13 after therapy.
Tumor sizes and body weight were measured.
Tumor samples were collected for immunohistochemical analysis of proliferation and microvessel density (MVD) with anti-Ki67 and anti-CD31, respectively.
Results.
The uptake ratios of tumor to the contralateral muscle (T/M) of 18F-FLT in the Sunitinib group decreased from baseline to day 3 (T/M0 = 2.98 ± 0.33; T/M3 = 2.23 ± 0.36; P<0.001), reached the bottom on day 7 (T/M7 = 1.96 ± 0.35; P<0.001), and then recovered on day 13.
The T/M of 18F-FLT uptake in the control group remained around 3.0.
There was no difference for the tumor size between both groups until day 11.
18F-FLT uptakes of tumor were correlated with Ki67 staining index and MVD.
Conclusion.
Early therapy response to Sunitinib could be predicted via 18F-FLT PET, which will contribute to monitoring antiangiogenesis treatment.
American Psychological Association (APA)
Bao, Xiao& Wang, Ming-Wei& Zhang, Yong-Ping& Zhang, Ying-Jian. 2014. Early Monitoring Antiangiogenesis Treatment Response of Sunitinib in U87MG Tumor Xenograft by 18F-FLT MicroPETCT Imaging. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455515
Modern Language Association (MLA)
Bao, Xiao…[et al.]. Early Monitoring Antiangiogenesis Treatment Response of Sunitinib in U87MG Tumor Xenograft by 18F-FLT MicroPETCT Imaging. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-455515
American Medical Association (AMA)
Bao, Xiao& Wang, Ming-Wei& Zhang, Yong-Ping& Zhang, Ying-Jian. Early Monitoring Antiangiogenesis Treatment Response of Sunitinib in U87MG Tumor Xenograft by 18F-FLT MicroPETCT Imaging. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455515