Maternal Diabetes in Pregnancy : Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory”
Joint Authors
Yessoufou, Akadiri
Moutairou, Kabirou
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The adverse outcomes on the offspring from maternal diabetes in pregnancy are substantially documented.
In this paper, we report main knowledge on impacts of maternal diabetes on early and long-term health of the offspring, with specific comments on maternal obesity.
The main adverse outcome on progenies from pregnancy complicated with maternal diabetes appears to be macrosomia, as it is commonly known that intrauterine exposure to hyperglycemia increases the risk and programs the offspring to develop diabetes and/or obesity at adulthood.
This “fetal programming”, due to intrauterine diabetic milieu, is termed as “metabolic memory”.
In gestational diabetes as well as in macrosomia, the complications include metabolic abnormalities, degraded antioxidant status, disrupted immune system and potential metabolic syndrome in adult offspring.
Furthermore, there is evidence that maternal obesity may also increase the risk of obesity and diabetes in offspring.
However, women with GDM possibly exhibit greater macrosomia than obese women.
Obesity and diabetes in pregnancy have independent and additive effects on obstetric complications, and both require proper management.
Management of gestational diabetes mellitus and maternal obesity is essential for maternal and offspring's good health.
Increasing physical activity, preventing gestational weight gain, and having some qualitative nutritional habits may be beneficial during both the pregnancy and offspring's future life.
American Psychological Association (APA)
Yessoufou, Akadiri& Moutairou, Kabirou. 2011. Maternal Diabetes in Pregnancy : Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory”. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455520
Modern Language Association (MLA)
Yessoufou, Akadiri& Moutairou, Kabirou. Maternal Diabetes in Pregnancy : Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory”. Experimental Diabetes Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-455520
American Medical Association (AMA)
Yessoufou, Akadiri& Moutairou, Kabirou. Maternal Diabetes in Pregnancy : Early and Long-Term Outcomes on the Offspring and the Concept of “Metabolic Memory”. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455520