Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis : A Review
Joint Authors
Benecke, Reiner
Abu-Mugheisib, Mazen
Zettl, Uwe K.
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
At the present time, anti-inflammatory, immunomodulatory, or immunosuppressive treatments of multiple sclerosis (MS) are mainly effective in the early phases of the disease but are of less advantage in progressive phases.
Current therapeutic strategies of both primary and secondary progressive MS are rare.
One alternative may be intrathecal application of triamcinolone acetonide (TCA).
Number of papers deal with advantages and disadvantages of intrathecal administration in MS.
Former trials lacked detailed selection of MS patients, with small sample sizes, low steroid dosages, and only a small number of intrathecal administration of short acting steroids.
The present paper summarizes recent trials performed following a different treatment regime.
They were conducted in patients with progressive MS suffering mainly from spinal symptoms and documented a significant improvement of EDSS and walking distance (WD).
Intrathecal TCA administration is a proposal to take into account as one therapy option in patients with a progressive clinical course and predominantly spinal symptoms.
American Psychological Association (APA)
Abu-Mugheisib, Mazen& Benecke, Reiner& Zettl, Uwe K.. 2011. Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis : A Review. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455552
Modern Language Association (MLA)
Abu-Mugheisib, Mazen…[et al.]. Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis : A Review. Multiple Sclerosis International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-455552
American Medical Association (AMA)
Abu-Mugheisib, Mazen& Benecke, Reiner& Zettl, Uwe K.. Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis : A Review. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455552