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Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers
Joint Authors
Sistla, Pavana Goury
Raj, T. Avinash
Jinka, Rajeswari
Kapoor, Renu
Pande, Gopal
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cancer progression is a multistep process during which normal cells exhibit molecular changes that culminate into the highly malignant and metastatic phenotype, observed in cancerous tissues.
The initiation of cell transformation is generally associated with genetic alterations in normal cells that lead to the loss of intercellular- and/or extracellular-matrix- (ECM-) mediated cell adhesion.
Transformed cells undergo rapid multiplication and generate more modifications in adhesion and motility-related molecules which allow them to escape from the original site and acquire invasive characteristics.
Integrins, which are multifunctional adhesion receptors, and are present, on normal as well as transformed cells, assist the cells undergoing tumor progression in creating the appropriate environment for their survival, growth, and invasion.
In this paper, we have briefly discussed the role of ECM proteins and integrins during cancer progression and described some unique conditions where adhesion-related changes could induce genetic mutations in anchorage-independent tumor model systems.
American Psychological Association (APA)
Jinka, Rajeswari& Kapoor, Renu& Sistla, Pavana Goury& Raj, T. Avinash& Pande, Gopal. 2012. Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455566
Modern Language Association (MLA)
Jinka, Rajeswari…[et al.]. Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-455566
American Medical Association (AMA)
Jinka, Rajeswari& Kapoor, Renu& Sistla, Pavana Goury& Raj, T. Avinash& Pande, Gopal. Alterations in Cell-Extracellular Matrix Interactions during Progression of Cancers. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455566