Treatment of Decompensated Alcoholic Liver Disease
Joint Authors
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alcoholic liver disease (ALD) is a spectrum ranging from simple hepatic steatosis to alcoholic hepatitis and cirrhosis.
Patients with severe alcoholic hepatitis can have clinical presentation almost similar to those with decompensated cirrhosis.
Scoring with models like Maddrey discriminant function, a model for end-stage liver disease, Glasgow alcoholic hepatitis score, and Lille model are helpful in prognosticating patients with ALD.
One of the first therapeutic goals in ALD is to induce alcohol withdrawal with psychotherapy or drugs.
Most studies have shown that nutritional therapy improves liver function and histology in patients with ALD.
The rationale for using glucocorticoids is to block cytotoxic and inflammatory pathways in patients with severe alcoholic hepatitis.
Pentoxifylline, a tumor necrosis factor alpha (TNFα) suppressor, and infliximab, an anti-TNFα mouse/human chimeric antibody, has been extensively studied in patients with alcoholic hepatitis.
Liver transplantation remains the definitive therapy for decompensated cirrhosis/alcoholic hepatitis despite the issues of recidivism, poor compliance with postoperative care, and being a self-inflicted disease.
American Psychological Association (APA)
Menachery, John& Duseja, Ajay. 2011. Treatment of Decompensated Alcoholic Liver Disease. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455570
Modern Language Association (MLA)
Menachery, John& Duseja, Ajay. Treatment of Decompensated Alcoholic Liver Disease. International Journal of Hepatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-455570
American Medical Association (AMA)
Menachery, John& Duseja, Ajay. Treatment of Decompensated Alcoholic Liver Disease. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455570