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Stat3 Expression and Its Correlation with Proliferation and ApoptosisAutophagy in Gliomas
Joint Authors
Caldera, Valentina
Schiffer, Davide
Valente, Guido
Mellai, Marta
Tessitore, Luciana
Annovazzi, Laura
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Signal transducer and activator of transcription-3 (Stat3) was studied along with several steps of the PI3/Akt pathway in a series of 64 gliomas that included both malignant and low-grade tumors, using quantitative immunohistochemistry, Western blotting, and molecular biology techniques.
The goal of the study was to investigate whether activated Stat3 (phospho-Stat3) levels correlated with cell proliferation, apoptosis, and autophagy.
Stat3 and activated Akt (phospho-Akt) expression increased with malignancy grade, but did not correlate with proliferation and survival within the category of glioblastomas.
A correlation of Stat3 with Akt was found, indicating a regulation of the former by the PI3/Akt pathway, which, in turn, was in relation with EGFR amplification.
Stat3 and Akt did not show any correlation with apoptosis, whereas they showed an inverse correlation with Beclin 1, a stimulator of autophagy, which was rarely positive in glioblastomas.
Autophagy seems then to be inactivated in malignant gliomas.
American Psychological Association (APA)
Caldera, Valentina& Mellai, Marta& Annovazzi, Laura& Valente, Guido& Tessitore, Luciana& Schiffer, Davide. 2009. Stat3 Expression and Its Correlation with Proliferation and ApoptosisAutophagy in Gliomas. Journal of Oncology،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-455571
Modern Language Association (MLA)
Caldera, Valentina…[et al.]. Stat3 Expression and Its Correlation with Proliferation and ApoptosisAutophagy in Gliomas. Journal of Oncology No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-455571
American Medical Association (AMA)
Caldera, Valentina& Mellai, Marta& Annovazzi, Laura& Valente, Guido& Tessitore, Luciana& Schiffer, Davide. Stat3 Expression and Its Correlation with Proliferation and ApoptosisAutophagy in Gliomas. Journal of Oncology. 2009. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-455571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455571