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Impact of KRAS Mutations on Management of Colorectal Carcinoma
Joint Authors
Sullivan, Kevin M.
Kozuch, Peter S.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The epidermal growth factor receptor (EGFR) pathway is a therapeutic target in the management of colorectal cancer (CRC).
EGFR antagonists are active in this disease; however, only a subset of patients respond to such therapy.
A Kirsten ras sarcoma viral oncogene (KRAS) wild-type (WT) status of the tumor is necessary, but possibly not sufficient, for a response to anti-EGFR monoclonal antibody therapy.
Mechanisms of primary resistance to such therapy in patients harboring KRAS WT tumors are discussed.
Strategies to overcome resistance to anti-EGFR monoclonal antibody therapy, including novel agents and combinations of novel therapies, are explored.
Also, the use of anti-EGFR monoclonal antibodies in the adjuvant and neoadjuvant setting is reviewed.
American Psychological Association (APA)
Sullivan, Kevin M.& Kozuch, Peter S.. 2011. Impact of KRAS Mutations on Management of Colorectal Carcinoma. Pathology Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455585
Modern Language Association (MLA)
Sullivan, Kevin M.& Kozuch, Peter S.. Impact of KRAS Mutations on Management of Colorectal Carcinoma. Pathology Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-455585
American Medical Association (AMA)
Sullivan, Kevin M.& Kozuch, Peter S.. Impact of KRAS Mutations on Management of Colorectal Carcinoma. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455585