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Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure
Joint Authors
Abreu, Nayda P.
Campos, Ruy R.
Oliveira-Sales, Elizabeth B.
Dugaich, Adriana P. Castilho
Bergamaschi, Cássia T.
Boim, Mirian A.
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sympathetic activation in chronic renal failure (CRF) is a major mechanism leading to the progression of renal disease and hypertension.
In the present study, we tested the hypothesis that in CRF increased reactive oxygen species (ROS) production in the RVLM mediated by enhanced circulating Angiotensin II (Ang II) is an important mechanism leading to hypertension in CRF.
In CRF rats we found an increase in the abundance of p47phox and gp91phox mRNA within the RVLM associated with a reduction of Ang II type 1 receptors (AT1) mRNA in the brainstem compared to controls (C).
Tempol but not candesartan into the RVLM decreased MAP in CRF but not in C rats.
GABA into the RVLM decreased MAP in CRF (63±8 mmHg) more intensely than in C (33±3 mmHg).
The results suggest that increased oxidative stress within the RVLM has an important participation to maintain hypertension in CRF rats apparently independently of AT1 Ang II receptors.
American Psychological Association (APA)
Dugaich, Adriana P. Castilho& Oliveira-Sales, Elizabeth B.& Abreu, Nayda P.& Boim, Mirian A.& Bergamaschi, Cássia T.& Campos, Ruy R.. 2011. Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-455591
Modern Language Association (MLA)
Dugaich, Adriana P. Castilho…[et al.]. Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure. International Journal of Hypertension No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-455591
American Medical Association (AMA)
Dugaich, Adriana P. Castilho& Oliveira-Sales, Elizabeth B.& Abreu, Nayda P.& Boim, Mirian A.& Bergamaschi, Cássia T.& Campos, Ruy R.. Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure. International Journal of Hypertension. 2011. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-455591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455591