Advantageous Uses of Mass Spectrometry for the Quantification of Proteins
Author
Source
International Journal of Proteomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Quantitative protein measurements by mass spectrometry have gained wide acceptance in research settings.
However, clinical uptake of mass spectrometric protein assays has not followed suit.
In part, this is due to the long-standing acceptance by regulatory agencies of immunological assays such as ELISA assays.
In most cases, ELISAs provide highly accurate, sensitive, relatively inexpensive, and simple assays for many analytes.
The barrier to acceptance of mass spectrometry in these situations will remain high.
However, mass spectrometry provides solutions to certain protein measurements that are difficult, if not impossible, to accomplish by immunological methods.
Cases where mass spectrometry can provide solutions to difficult assay development include distinguishing between very closely related protein species and monitoring biological and analytical variability due to sample handling and very high multiplexing capacity.
This paper will highlight several examples where mass spectrometry has made certain protein measurements possible where immunological techniques have had a great difficulty.
American Psychological Association (APA)
Hale, John E.. 2013. Advantageous Uses of Mass Spectrometry for the Quantification of Proteins. International Journal of Proteomics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455603
Modern Language Association (MLA)
Hale, John E.. Advantageous Uses of Mass Spectrometry for the Quantification of Proteins. International Journal of Proteomics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-455603
American Medical Association (AMA)
Hale, John E.. Advantageous Uses of Mass Spectrometry for the Quantification of Proteins. International Journal of Proteomics. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455603