Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2PI3KAkt Signaling Pathway
Joint Authors
Hsu, Shih-Chung
Tseng, Hsiu-Hsueh
Kuo, Han-Peng
Li, Jhy-Wei
Chuang, Tzu-Chao
Ou, Chien-Chih
Liu, Jah-Yao
Cheng, Yung-Chi
Su, Muh-Hwan
Chou, Wei-Yuan
Chen, Shih-Jung
Kao, Ming-Ching
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries.
It is a medicinal fungus with a variety of biological properties including immunomodulatory and antitumor activities.
In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, inhibits the proliferation of HER2-overexpressing cancer cells.
Here, we show that a quality assured extract of GT (GTE) inhibited the growth of HER2-overexpressing cancer cells in vitro and in vivo and enhanced the growth-inhibitory effect of antitumor drugs (e.g., taxol and cisplatin) in these cells.
We also demonstrate that GTE induced cell cycle arrest by interfering with the HER2/PI3K/Akt signaling pathway.
Furthermore, GTE curtailed the expression of the HER2 protein by modulating the transcriptional activity of the HER2 gene and the stability/degradation of the HER2 protein.
In conclusion, this study suggests that GTE may be a useful adjuvant therapeutic agent in the treatment of cancer cells that highly express HER2.
American Psychological Association (APA)
Kuo, Han-Peng& Hsu, Shih-Chung& Ou, Chien-Chih& Li, Jhy-Wei& Tseng, Hsiu-Hsueh& Chuang, Tzu-Chao…[et al.]. 2013. Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-455606
Modern Language Association (MLA)
Kuo, Han-Peng…[et al.]. Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-455606
American Medical Association (AMA)
Kuo, Han-Peng& Hsu, Shih-Chung& Ou, Chien-Chih& Li, Jhy-Wei& Tseng, Hsiu-Hsueh& Chuang, Tzu-Chao…[et al.]. Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2PI3KAkt Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-455606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455606