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Autophagy : More Than a Nonselective Pathway
Joint Authors
Reggiori, Fulvio
Finley, Kim
Simonsen, Anne
Komatsu, Masaaki
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly eliminate large unwanted structures such as aberrant protein aggregates, superfluous or damaged organelles, and invading pathogens.
The hallmark of this transport pathway is the sequestration of the cargoes that have to be degraded in the lysosomes by double-membrane vesicles called autophagosomes.
The key actors mediating the biogenesis of these carriers are the autophagy-related genes (ATGs).
For a long time, it was assumed that autophagy is a bulk process.
Recent studies, however, have highlighted the capacity of this pathway to exclusively eliminate specific structures and thus better fulfil the catabolic necessities of the cell.
We are just starting to unveil the regulation and mechanism of these selective types of autophagy, but what it is already clearly emerging is that structures targeted to destruction are accurately enwrapped by autophagosomes through the action of specific receptors and adaptors.
In this paper, we will briefly discuss the impact that the selective types of autophagy have had on our understanding of autophagy.
American Psychological Association (APA)
Reggiori, Fulvio& Komatsu, Masaaki& Finley, Kim& Simonsen, Anne. 2012. Autophagy : More Than a Nonselective Pathway. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-455625
Modern Language Association (MLA)
Reggiori, Fulvio…[et al.]. Autophagy : More Than a Nonselective Pathway. International Journal of Cell Biology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-455625
American Medical Association (AMA)
Reggiori, Fulvio& Komatsu, Masaaki& Finley, Kim& Simonsen, Anne. Autophagy : More Than a Nonselective Pathway. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-455625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455625