Identification and Molecular Characterization of Molluskin, a Histone-H2A-Derived Antimicrobial Peptide from Molluscs
Joint Authors
Philip, Rosamma
Anil Kumar, P. R.
Chaithanya, E. R.
Sathyan, Naveen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Antimicrobial peptides are humoral innate immune components of molluscs that provide protection against pathogenic microorganisms.
Among these, histone-H2A-derived antimicrobial peptides are known to actively participate in host defense responses of molluscs.
Present study deals with identification of putative antimicrobial sequences from the histone-H2A of back-water oyster Crassostrea madrasensis, rock oyster Saccostrea cucullata, grey clam Meretrix casta, fig shell Ficus gracilis, and ribbon bullia Bullia vittata.
A 75 bp fragment encoding 25 amino acid residues was amplified from cDNA of these five bivalves and was named “Molluskin.” The 25 amino acid peptide exhibited high similarity to previously reported histone-H2A-derived AMPs from invertebrates indicating the presence of an antimicrobial sequence motif.
Physicochemical properties of the peptides are in agreement with the characteristic features of antimicrobial peptides, indicating their potential role in innate immunity of molluscs.
American Psychological Association (APA)
Sathyan, Naveen& Philip, Rosamma& Chaithanya, E. R.& Anil Kumar, P. R.. 2012. Identification and Molecular Characterization of Molluskin, a Histone-H2A-Derived Antimicrobial Peptide from Molluscs. ISRN Molecular Biology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455630
Modern Language Association (MLA)
Sathyan, Naveen…[et al.]. Identification and Molecular Characterization of Molluskin, a Histone-H2A-Derived Antimicrobial Peptide from Molluscs. ISRN Molecular Biology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-455630
American Medical Association (AMA)
Sathyan, Naveen& Philip, Rosamma& Chaithanya, E. R.& Anil Kumar, P. R.. Identification and Molecular Characterization of Molluskin, a Histone-H2A-Derived Antimicrobial Peptide from Molluscs. ISRN Molecular Biology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455630