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Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
Joint Authors
Uranga, Romina M.
Keller, Jeffrey N.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis.
An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia.
Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain.
Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown.
This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
American Psychological Association (APA)
Uranga, Romina M.& Keller, Jeffrey N.. 2010. Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis. Current Gerontology and Geriatrics Research،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-455632
Modern Language Association (MLA)
Uranga, Romina M.& Keller, Jeffrey N.. Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis. Current Gerontology and Geriatrics Research No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-455632
American Medical Association (AMA)
Uranga, Romina M.& Keller, Jeffrey N.. Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis. Current Gerontology and Geriatrics Research. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-455632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455632