Diabetic Ketoacidosis-Associated Stroke in Children and Youth
Joint Authors
Morrison, Gavin
Foster, Jennifer Ruth
Fraser, Douglas D.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic ketoacidosis (DKA) is a state of severe insulin deficiency, either absolute or relative, resulting in hyperglycemia and ketonemia.
Although possibly underappreciated, up to 10% of cases of intracerebral complications associated with an episode of DKA, and/or its treatment, in children and youth are due to hemorrhage or ischemic brain infarction.
Systemic inflammation is present in DKA, with resultant vascular endothelial perturbation that may result in coagulopathy and increased hemorrhagic risk.
Thrombotic risk during DKA is elevated by abnormalities in coagulation factors, platelet activation, blood volume and flow, and vascular reactivity.
DKA-associated cerebral edema may also predispose to ischemic injury and hemorrhage, though cases of stroke without concomitant cerebral edema have been identified.
We review the current literature regarding the pathogenesis of stroke during an episode of DKA in children and youth.
American Psychological Association (APA)
Foster, Jennifer Ruth& Morrison, Gavin& Fraser, Douglas D.. 2011. Diabetic Ketoacidosis-Associated Stroke in Children and Youth. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455635
Modern Language Association (MLA)
Foster, Jennifer Ruth…[et al.]. Diabetic Ketoacidosis-Associated Stroke in Children and Youth. Stroke Research and Treatment No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-455635
American Medical Association (AMA)
Foster, Jennifer Ruth& Morrison, Gavin& Fraser, Douglas D.. Diabetic Ketoacidosis-Associated Stroke in Children and Youth. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455635