Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion
Joint Authors
Nabika, Toru
Nagasaki, Makoto
Ishida, Katsunari
Nakagawa, Tatsushi
Kobayashi, Masayuki
Taniyama, Kiyomi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To examine the diagnostic utility for squamous intraepithelial lesion (SIL) by cytological in situ hybridization (c-ISH) for the human papillomavirus using liquid-based cytology specimens, we investigated c-ISH signal patterns in the cases of low-grade SIL (LSIL), atypical squamous cells of undetermined significance (ASC-US), and high-grade SIL (HSIL).
Episomal (E) and/or integrated (I) signals were observed.
Two signal patterns (E≧I or I>E) were obtained by counting the number of E+ or I+ cells.
E≧I was specific to LSIL and ASC-US (10/12); I>E, to HSIL (9/11) (P<0.01, χ2 test), suggesting significant utility of c-ISH in diagnosing SIL.
In the cell fraction, E≧I in large cells was dominant in LSIL.
Two cases of I>E in large cells of LSIL showed HPV persistence and/or progression during follow-up.
Thus, c-ISH is useful in routine testing for diagnosing cervical dysplastic lesions, especially for detecting LSIL suspected for progression.
American Psychological Association (APA)
Ishida, Katsunari& Nagasaki, Makoto& Kobayashi, Masayuki& Nakagawa, Tatsushi& Nabika, Toru& Taniyama, Kiyomi. 2011. Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion. ISRN Pathology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455641
Modern Language Association (MLA)
Ishida, Katsunari…[et al.]. Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion. ISRN Pathology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-455641
American Medical Association (AMA)
Ishida, Katsunari& Nagasaki, Makoto& Kobayashi, Masayuki& Nakagawa, Tatsushi& Nabika, Toru& Taniyama, Kiyomi. Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-455641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455641