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“Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors
Joint Authors
Widegren, Bengt
Nittby, Henrietta
Grafström, Gustav
Salford, Leif G.
Persson, Bertil R. R.
Bauréus Koch, Catrin
Munck af Rosenschöld, Per
Ceberg, Crister
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The tumor growth rate response was studied on N29 rat glioma tumor cells subcutaneously implanted on both hind legs of Fischer-344 rats.
At around 30 days after inoculation, RT was given with 60Co gamma radiation with 4 daily fractions of 5 Gy only to the right-lateral tumors.
At days 26, 42, and 54 after inoculation, immunization was performed with irradiated syngeneic IFNγ-gene transfected cells.
Tumor growth rate (TGR % per day) of the right-lateral irradiated tumor was significantly decreased (P<0.01) after RT alone and with the combination of RT and immunization.
But immunization alone gave no significant decrease of the TGR but significantly increased time of survival.
The TGR of the unirradiated left-lateral tumors was significantly decreased (P<0.02) only in the group of rats treated with RT alone.
It is apparent that tumor cells killed by the radiation mediate suppression of tumor cells outside the target area.
This effect is called the abscopal effect.
American Psychological Association (APA)
Persson, Bertil R. R.& Bauréus Koch, Catrin& Grafström, Gustav& Ceberg, Crister& Munck af Rosenschöld, Per& Nittby, Henrietta…[et al.]. 2011. “Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors. ISRN Immunology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-455650
Modern Language Association (MLA)
Persson, Bertil R. R.…[et al.]. “Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors. ISRN Immunology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-455650
American Medical Association (AMA)
Persson, Bertil R. R.& Bauréus Koch, Catrin& Grafström, Gustav& Ceberg, Crister& Munck af Rosenschöld, Per& Nittby, Henrietta…[et al.]. “Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors. ISRN Immunology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-455650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455650