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Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma
Joint Authors
Álvarez Marcos, César
Hermsen, Mario A.
Vivanco, Blanca
Perez-Escuredo, Jhudit
Fresno, Manuel Florentino
Llorente, José Luis
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited.
Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression.
Mild dysplasia was observed in 14%, cuboidal metaplasia in 57%, intestinal metaplasia in 8%, squamous metaplasia in 24%, and cylindrocellular hyperplasia in 53% of cases.
P53 immunopositivity was generally weak occurring most frequently in squamous metaplasia.
Wood dust etiology did not appear of influence on the histological changes, but p53 showed a tendency for higher positivity.
Dysplasia adjacent to tumor was indicative of subsequent development of recurrence.
In conclusion, precursor lesions do occur in mucosa adjacent to ITAC.
This is clinically important, because it may justify the screening of high-risk individuals such as woodworkers.
American Psychological Association (APA)
Vivanco, Blanca& Llorente, José Luis& Perez-Escuredo, Jhudit& Álvarez Marcos, César& Fresno, Manuel Florentino& Hermsen, Mario A.. 2011. Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma. Pathology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455653
Modern Language Association (MLA)
Vivanco, Blanca…[et al.]. Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma. Pathology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-455653
American Medical Association (AMA)
Vivanco, Blanca& Llorente, José Luis& Perez-Escuredo, Jhudit& Álvarez Marcos, César& Fresno, Manuel Florentino& Hermsen, Mario A.. Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455653