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Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl CelluloseBioCBone Morphogenic Protein-2 Hybrid Materials
Joint Authors
Kim, Hak-Jun
Song, Sang-Heon
Yun, Young-Pil
Park, Kyeongsoon
Song, Hae-Ryong
Kim, Sung Eun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to assess whether carboxymethyl cellulose- (CMC-) based hydrogel containing BioC (biphasic calcium phosphate (BCP); tricalcium phosphate (TCP) : hydroxyapatite (Hap) = 70 : 30) and bone morphogenic protein-2 (BMP-2) led to greater bone formation than CMC-based hydrogel containing BioC without BMP-2.
In order to demonstrate bone formation at 4 and 8 weeks, plain radiographs, microcomputed tomography (micro-CT) evaluation, and histological studies were performed after implantation of all hybrid materials on an 8 mm defect of the right tibia in rats.
The plain radiographs and micro-CT analyses revealed that CMC/BioC/BMP-2 (0.5 mg) led to much greater mineralization at 4 and 8 weeks than did CMC/BioC or CMC/Bio/BMP-2 (0.1 mg).
Likewise, bone formation and bone remodeling studies revealed that CMC/BioC/BMP-2 (0.5 mg) led to a significantly greater amount of bone formation and bone remodeling at 4 and 8 weeks than did CMC/BioC or CMC/BioC/BMP-2 (0.1 mg).
Histological studies revealed that mineralized bone tissue was present around the whole circumference of the defect site with CMC/BioC/BMP-2 (0.5 mg) but not with CMC/BioC or CMC/BioC/BMP-2 (0.1 mg) at 4 and 8 weeks.
These results suggest that CMC/BioC/BMP-2 hybrid materials induced greater bone formation than CMC/BioC hybrid materials.
Thus, CMC/BioC/BMP-2 hybrid materials may be used as an injectable substrate to regenerate bone defects.
American Psychological Association (APA)
Song, Sang-Heon& Yun, Young-Pil& Kim, Hak-Jun& Park, Kyeongsoon& Kim, Sung Eun& Song, Hae-Ryong. 2014. Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl CelluloseBioCBone Morphogenic Protein-2 Hybrid Materials. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-455654
Modern Language Association (MLA)
Song, Sang-Heon…[et al.]. Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl CelluloseBioCBone Morphogenic Protein-2 Hybrid Materials. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-455654
American Medical Association (AMA)
Song, Sang-Heon& Yun, Young-Pil& Kim, Hak-Jun& Park, Kyeongsoon& Kim, Sung Eun& Song, Hae-Ryong. Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl CelluloseBioCBone Morphogenic Protein-2 Hybrid Materials. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-455654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455654