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Posttransplant Lymphoproliferative Disorders
Joint Authors
Naresh, Kikkeri N.
Ibrahim, Hazem A. H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Posttransplant lymphoproliferative disorders (PTLDs) are a group of diseases that range from benign polyclonal to malignant monoclonal lymphoid proliferations.
They arise secondary to treatment with immunosuppressive drugs given to prevent transplant rejection.
Three main pathologic subsets/stages of evolution are recognised: early, polymorphic, and monomorphic lesions.
The pathogenesis of PTLDs seems to be multifactorial.
Among possible infective aetiologies, the role of EBV has been studied in depth, and the virus is thought to play a central role in driving the proliferation of EBV-infected B cells that leads to subsequent development of the lymphoproliferative disorder.
It is apparent, however, that EBV is not solely responsible for the “neoplastic” state.
Accumulated genetic alterations of oncogenes and tumour suppressor genes (deletions, mutations, rearrangements, and amplifications) and epigenetic changes (aberrant hypermethylation) that involve tumour suppressor genes are integral to the pathogenesis.
Antigenic stimulation also plays an evident role in the pathogenesis of PTLDs.
Plasmacytoid dendritic cells (PDCs) that are critical to fight viral infections have been thought to play a pathogenetically relevant role in PTLDs.
Furthermore, regulatory T cells (Treg cells), which are modulators of immune reactions once incited, seem to have an important role in PTLDs where antigenic stimulation is key for the pathogenesis.
American Psychological Association (APA)
Ibrahim, Hazem A. H.& Naresh, Kikkeri N.. 2012. Posttransplant Lymphoproliferative Disorders. Advances in Hematology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-455656
Modern Language Association (MLA)
Ibrahim, Hazem A. H.& Naresh, Kikkeri N.. Posttransplant Lymphoproliferative Disorders. Advances in Hematology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-455656
American Medical Association (AMA)
Ibrahim, Hazem A. H.& Naresh, Kikkeri N.. Posttransplant Lymphoproliferative Disorders. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-455656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455656