CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer
Joint Authors
Zhou, Liang
Zhong, Wei-de
Zhu, Jian-guo
Liang, Yu-xiang
Chen, Guo
He, Hui-chan
Bi, Xue-cheng
Fu, Hao
Chen, Yan-fei
Fu, Xin
Mo, Ru-jun
Jiang, Fu-neng
Wu, Yong-ding
Yang, Sheng-bang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aim.
CC chemokine ligand 18 (CCL18) promotes malignant behaviors of various human cancer types.
However, its involvement in human prostate cancer has not been fully elucidated.
The aim of this study was to investigate the role of CCL18 in PCa.
Methods.
Expression of CCL18 at mRNA and protein levels was detected using real-time qRT-PCR and immunohistochemistry analysis.
We analyzed the associations of CCL18 expression with clinical features of human PCa.
The effects of PCa cell migration, invasion, and apoptosis were tested.
The efficiency of CCL18 on prostate tumor growth was assessed in a subcutaneous xenograft model.
Results.
CCL18 expression was upregulated (both P<0.01) in PCa tissues compared with those in noncancerous prostate tissues.
CCL18 upregulation was correlated with high Gleason score (P=0.034) of patients with PCa.
rCCL18 stimulation in PCa cells promoted cell migration and invasion but decreased DU145 cells apoptosis rate.
Furthermore, subcutaneous homografts models showed the increased tumor growth and tumor vascularization with the CCL18 stimulation, and the expression of Ki67, PCNA, and CD31 in CCL18 stimulation mice was also significantly increased.
Conclusions.
Our data offer the convincing evidence that the upregulation of CCL18 may be involved in the malignant progression of PCa.
American Psychological Association (APA)
Chen, Guo& Liang, Yu-xiang& Zhu, Jian-guo& Fu, Xin& Chen, Yan-fei& Mo, Ru-jun…[et al.]. 2014. CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-455658
Modern Language Association (MLA)
Chen, Guo…[et al.]. CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-455658
American Medical Association (AMA)
Chen, Guo& Liang, Yu-xiang& Zhu, Jian-guo& Fu, Xin& Chen, Yan-fei& Mo, Ru-jun…[et al.]. CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-455658
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455658