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Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride
Joint Authors
Ghosh, Amitava
Roy, Amitava
Chakraborty, Prithviraj
Deb, Jyotirmoy
Banerjee, Pritam
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Purpose.
The objective of the proposed work is to evaluate the efficacy of Pectins to qualify them as polymers for designing an oral microsphere for the delivery of selected oral antidiabetic drug-like metformin hydrochloride.
Methods.
Different Microspheres formulations were prepared by the water in oil (w\o) emulsion solvent evaporation technique and subsequently evaluated for its different physical parameters as well as its in vitro and in vivo drug release study.
Results.
The formulations F2 (98.42) and F3 (98.03) showed a constant and high release in the dissolution profile, so among these two formulations, F2 was taken for development study, due to the better result shown over in other evaluation parameters.
From the HPLC determinations after in vivo study, it had been found that the test samples and the standard sample had not shown any significant fluctuation in relation to their retention time.
Conclusion.
From in vitro and in vivo results, it may be concluded that drug-loaded pectin microspheres in 1 : 1 ratio are a suitable delivery system for metformin hydrochloride and may be used for effective management of NIDDM.
From this experiment, it could be concluded that as a natural polymer, pectin has potentiality in novel drug delivery system.
American Psychological Association (APA)
Banerjee, Pritam& Deb, Jyotirmoy& Roy, Amitava& Ghosh, Amitava& Chakraborty, Prithviraj. 2012. Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride. ISRN Pharmaceutics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-455705
Modern Language Association (MLA)
Banerjee, Pritam…[et al.]. Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride. ISRN Pharmaceutics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-455705
American Medical Association (AMA)
Banerjee, Pritam& Deb, Jyotirmoy& Roy, Amitava& Ghosh, Amitava& Chakraborty, Prithviraj. Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride. ISRN Pharmaceutics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-455705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455705