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Aromatase Activity and Bone Loss in Men
Joint Authors
Nuti, Ranuccio
Merlotti, Daniela
Gennari, Luigi
Stolakis, Konstantinos
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens.
This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone.
The activity of aromatase regulates the concentrations of estrogens with endocrine, paracrine, and autocrine effects on target issues including bone.
Importantly, extraglandular aromatization of circulating androgen precursors is the major source of estrogen in men.
Clinical and experimental evidences clearly indicate that aromatase activity and estrogen production are necessary for longitudinal bone growth, the attainment of peak bone mass, pubertal growth spurt, epiphyseal closure, and normal bone remodeling in young individuals.
Moreover, with aging, individual differences in aromatase activity may significantly affect bone loss and fracture risk in men.
American Psychological Association (APA)
Merlotti, Daniela& Gennari, Luigi& Stolakis, Konstantinos& Nuti, Ranuccio. 2011. Aromatase Activity and Bone Loss in Men. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455715
Modern Language Association (MLA)
Merlotti, Daniela…[et al.]. Aromatase Activity and Bone Loss in Men. Journal of Osteoporosis No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-455715
American Medical Association (AMA)
Merlotti, Daniela& Gennari, Luigi& Stolakis, Konstantinos& Nuti, Ranuccio. Aromatase Activity and Bone Loss in Men. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-455715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455715