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Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy : Aspects of Interest in Clinical Obstetrics
Joint Authors
Rudge, Marilza Vieira Cunha
Calderon, Iracema de Mattos Paranhos
Cirino Ruocco, Ana Maria
Vernini, Joice Monaliza
Brogin Moreli, Jusciele
Source
ISRN Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The purpose of this study was to review the literature regarding the action of the cytokines interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnancy and to emphasize the factors that are of interest to clinical obstetrics.
The literature highlights several actions of IL-10 and TNF-α during pregnancy.
The actions of these cytokines seem to be antagonistic and dependent on the balance between them, which is orchestrated by the specific immunosuppressive action of IL-10.
TNF-α has a characteristic inflammatory action, and it is an additional diabetogenic factor in pregnancy.
The loss of the control of the production of these cytokines, with increase of TNF-α, is related to the risk for developing obstetric complications, particularly recurrent fetal loss, gestational diabetes mellitus, hypertensive syndromes, and fetal growth restriction.
However, study results are controversial and are not clearly defined.
These issues are attributed to the heterogeneity of the studies, particularly regarding their sample sizes and sources, the evaluation methods, and the multiplicity of factors and conditions that influence cytokine production.
These questions are fundamental and should be addressed in future investigations to obtain more consistent results that can be applied to obstetric practice.
American Psychological Association (APA)
Brogin Moreli, Jusciele& Cirino Ruocco, Ana Maria& Vernini, Joice Monaliza& Rudge, Marilza Vieira Cunha& Calderon, Iracema de Mattos Paranhos. 2012. Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy : Aspects of Interest in Clinical Obstetrics. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-455724
Modern Language Association (MLA)
Brogin Moreli, Jusciele…[et al.]. Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy : Aspects of Interest in Clinical Obstetrics. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-455724
American Medical Association (AMA)
Brogin Moreli, Jusciele& Cirino Ruocco, Ana Maria& Vernini, Joice Monaliza& Rudge, Marilza Vieira Cunha& Calderon, Iracema de Mattos Paranhos. Interleukin 10 and Tumor Necrosis Factor-Alpha in Pregnancy : Aspects of Interest in Clinical Obstetrics. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-455724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455724