Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine : A Behavioral and Electrophysiological Approach
Joint Authors
Gutierrez, Stanley J. C.
Barreto, Rosana S. S.
Barbosa Filho, José Maria
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Quintans-Júnior, Lucindo J.
Almeida, Reinaldo Nóbrega de
Santana-Filho, Valter J.
Lucca Júnior, Waldecy De
Araújo, Demétrius A. M.
DeSantana, Josimari Melo
Silva, Davi A.
Quintans, Jullyana S. S.
Souza, Maria F. V.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.).
This effect was not antagonized by naloxone (1.5 mg/kg, i.p.).
NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test.
Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST.
Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude.
NST might represent an important tool for pain management.
American Psychological Association (APA)
Quintans-Júnior, Lucindo J.& Silva, Davi A.& Quintans, Jullyana S. S.& Araújo, Adriano Antunes de Souza& Barreto, Rosana S. S.& Bonjardim, Leonardo Rigoldi…[et al.]. 2010. Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine : A Behavioral and Electrophysiological Approach. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-455725
Modern Language Association (MLA)
Quintans-Júnior, Lucindo J.…[et al.]. Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine : A Behavioral and Electrophysiological Approach. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-455725
American Medical Association (AMA)
Quintans-Júnior, Lucindo J.& Silva, Davi A.& Quintans, Jullyana S. S.& Araújo, Adriano Antunes de Souza& Barreto, Rosana S. S.& Bonjardim, Leonardo Rigoldi…[et al.]. Bioassay-Guided Evaluation of Antinociceptive Effect of N-Salicyloyltryptamine : A Behavioral and Electrophysiological Approach. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-455725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455725