Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease) : Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy
Joint Authors
González, Carmen
Bleda, Silvia
Acin, Francisco
López de Maturana, Ignacio
de Haro, Joaquín
Rodriguez-Padilla, Javier
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thromboangiitis obliterans (TAO) or Buerger's disease is associated with both distal ulcers in the extremities and the possibility of amputation.
The only treatment that has been shown to be effective in TAO is complete abstention from smoking.
In spite of this, the disease progresses in up to 30 percent of cases and finally results in limb amputation.
Only a few pharmacological and surgical options are available to date to improve healing ulcers in TAO.
The efficacy of prostaglandin analogues is controversial.
This paper summarizes the current evidence for medical treatment with bosentan in chronic ulcers in TAO patients.
These available data up to date allow us to conclude that the beneficial effects of bosentan on improving endothelial function, inflammatory processes, and selective vasodilatation of damaged vessels result in a clinical enhancement regarding healing and preventive digital ulcers in such patients.
In any case, these promising findings have to be confirmed with larger randomised trials.
American Psychological Association (APA)
López de Maturana, Ignacio& Rodriguez-Padilla, Javier& González, Carmen& Bleda, Silvia& de Haro, Joaquín& Acin, Francisco. 2013. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease) : Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy. Ulcers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455727
Modern Language Association (MLA)
López de Maturana, Ignacio…[et al.]. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease) : Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy. Ulcers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-455727
American Medical Association (AMA)
López de Maturana, Ignacio& Rodriguez-Padilla, Javier& González, Carmen& Bleda, Silvia& de Haro, Joaquín& Acin, Francisco. Chronic Ulcers in Thromboangiitis Obliterans (Buerger's Disease) : Updating Epidemiology, Physiopathology, and Bosentan—A Novel Strategy of Therapy. Ulcers. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455727