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Accelerated Aging in Major Depression : The Role of Nitro-Oxidative Stress
Joint Authors
Luca, Maria
Luca, Antonina
Calandra, Carmela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD).
The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature mortality; all of these conditions find an explanation in an altered redox homeostasis.
If aging, neurodegeneration, and major depression share a common biological base in their pathophysiology, common therapeutic tools could be investigated for the prevention and treatment of these disorders.
As an example, antidepressants have been demonstrated to present neuroprotective and anti-inflammatory properties and to stimulate neurogenesis.
In parallel, antioxidants that stimulate the antioxidant defense systems and interact with the monoaminergic system show an antidepressant-like activity.
Further research on this topic could lead, in the near future, to the expansion of the therapeutic possibilities for the treatment of NOS-related disorders.
American Psychological Association (APA)
Luca, Maria& Luca, Antonina& Calandra, Carmela. 2013. Accelerated Aging in Major Depression : The Role of Nitro-Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455730
Modern Language Association (MLA)
Luca, Maria…[et al.]. Accelerated Aging in Major Depression : The Role of Nitro-Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-455730
American Medical Association (AMA)
Luca, Maria& Luca, Antonina& Calandra, Carmela. Accelerated Aging in Major Depression : The Role of Nitro-Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-455730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455730