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Unexplained Graft Dysfunction after Heart Transplantation—Role of Novel Molecular Expression Test Score and QTc-Interval : A Case Report
Joint Authors
Cadeiras, Martin
Shahzad, Khurram
Arai, Kotaro
Deng, Mario C.
Burke, Elizabeth
Abramov, Dmitry
Source
Cardiology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In the current era of immunosuppressive medications there is increased observed incidence of graft dysfunction in the absence of known histological criteria of rejection after heart transplantation.
A noninvasive molecular expression diagnostic test was developed and validated to rule out histological acute cellular rejection.
In this paper we present for the first time, longitudinal pattern of changes in this novel diagnostic test score along with QTc-interval in a patient who was admitted with unexplained graft dysfunction.
Patient presented with graft failure with negative findings on all known criteria of rejection including acute cellular rejection, antibody mediated rejection and cardiac allograft vasculopathy.
The molecular expression test score showed gradual increase and QTc-interval showed gradual prolongation with the gradual decline in graft function.
This paper exemplifies that in patients presenting with unexplained graft dysfunction, GEP test score and QTc-interval correlate with the changes in the graft function.
American Psychological Association (APA)
Shahzad, Khurram& Cadeiras, Martin& Arai, Kotaro& Abramov, Dmitry& Burke, Elizabeth& Deng, Mario C.. 2010. Unexplained Graft Dysfunction after Heart Transplantation—Role of Novel Molecular Expression Test Score and QTc-Interval : A Case Report. Cardiology Research and Practice،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-455731
Modern Language Association (MLA)
Shahzad, Khurram…[et al.]. Unexplained Graft Dysfunction after Heart Transplantation—Role of Novel Molecular Expression Test Score and QTc-Interval : A Case Report. Cardiology Research and Practice No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-455731
American Medical Association (AMA)
Shahzad, Khurram& Cadeiras, Martin& Arai, Kotaro& Abramov, Dmitry& Burke, Elizabeth& Deng, Mario C.. Unexplained Graft Dysfunction after Heart Transplantation—Role of Novel Molecular Expression Test Score and QTc-Interval : A Case Report. Cardiology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-455731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455731