Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus : Four Factors with Potential Therapeutic Interest
Joint Authors
Gauthier, Benoit R.
Mellado-Gil, Jose Manuel
Cobo-Vuilleumier, Nadia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Islet β-cell replacement and regeneration are two promising approaches for the treatment of Type 1 Diabetes Mellitus.
Indeed, the success of islet transplantation in normalizing blood glucose in diabetic patients has provided the proof of principle that cell replacement can be employed as a safe and efficacious treatment.
Nonetheless, shortage of organ donors has hampered expansion of this approach.
Alternative sources of insulin-producing cells are mandatory to fill this gap.
Although great advances have been achieved in generating surrogate β-cells from stem cells, current protocols have yet to produce functionally mature insulin-secreting cells.
Recently, the concept of islet regeneration in which new β-cells are formed from either residual β-cell proliferation or transdifferentiation of other endocrine islet cells has gained much interest as an attractive therapeutic alternative to restore β-cell mass.
Complementary approaches to cell replacement and regeneration could aim at enhancing β-cell survival and function.
Herein, we discuss the value of Hepatocyte Growth Factor (HGF), Glucose-Dependent Insulinotropic Peptide (GIP), Paired box gene 4 (Pax4) and Liver Receptor Homolog-1 (LRH-1) as key players for β-cell replacement and regeneration therapies.
These factors convey β-cell protection and enhanced function as well as facilitating proliferation and transdifferentiation of other pancreatic cell types to β-cells, under stressful conditions.
American Psychological Association (APA)
Mellado-Gil, Jose Manuel& Cobo-Vuilleumier, Nadia& Gauthier, Benoit R.. 2012. Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus : Four Factors with Potential Therapeutic Interest. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-455742
Modern Language Association (MLA)
Mellado-Gil, Jose Manuel…[et al.]. Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus : Four Factors with Potential Therapeutic Interest. Journal of Transplantation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-455742
American Medical Association (AMA)
Mellado-Gil, Jose Manuel& Cobo-Vuilleumier, Nadia& Gauthier, Benoit R.. Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus : Four Factors with Potential Therapeutic Interest. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-455742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455742