Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics during In Vivo Repeated Allergen Skin Challenges in Atopic Subjects
Joint Authors
Aggelakopoulou, Maria
Zervas, Eleftherios
Semitekolou, Maria
Gaga, Mina
Xanthou, Georgina
Samitas, Konstantinos
Vittorakis, Stelios
Panoutsakopoulou, Vily
Tousa, Sofia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Upon allergen challenge, DC subsets are recruited to target sites under the influence of chemotactic agents; however, details pertinent to their trafficking remain largely unknown.
We investigated the kinetic profiles of blood and skin-infiltrating DC subsets in twelve atopic subjects receiving six weekly intradermal allergen and diluent injections.
The role of activin-A, a cytokine induced in allergic and tissue repair processes, on the chemotactic profiles of DC subsets was also examined.
Plasmacytoid (pDCs) and conventional DCs (cDCs) were evaluated at various time-points in the blood and skin.
In situ activin-A expression was assessed in the skin and its effects on chemokine receptor expression of isolated cDCs were investigated.
Blood pDCs were reduced 1 h after challenge, while cDCs decreased gradually within 24 h.
Skin cDCs increased significantly 24 h after the first challenge, inversely correlating with blood cDCs.
Activin-A in the skin increased 24 h after the first allergen challenge and correlated with infiltrating cDCs.
Activin-A increased the CCR10/CCR4 expression ratio in cultured human cDCs.
DC subsets demonstrate distinct kinetic profiles in the blood and skin especially during acute allergic inflammation, pointing to disparate roles depending on each phase of the inflammatory response.
The effects of activin-A on modulating the chemotactic profile of cDCs suggest it may be a plausible therapeutic target for allergic diseases.
American Psychological Association (APA)
Vittorakis, Stelios& Samitas, Konstantinos& Tousa, Sofia& Zervas, Eleftherios& Aggelakopoulou, Maria& Semitekolou, Maria…[et al.]. 2014. Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics during In Vivo Repeated Allergen Skin Challenges in Atopic Subjects. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455759
Modern Language Association (MLA)
Vittorakis, Stelios…[et al.]. Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics during In Vivo Repeated Allergen Skin Challenges in Atopic Subjects. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-455759
American Medical Association (AMA)
Vittorakis, Stelios& Samitas, Konstantinos& Tousa, Sofia& Zervas, Eleftherios& Aggelakopoulou, Maria& Semitekolou, Maria…[et al.]. Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics during In Vivo Repeated Allergen Skin Challenges in Atopic Subjects. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455759