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The Association of HLA-Class I and Class II with Hodgkin’s Lymphoma in Iranian Patients
Joint Authors
Hajifathali, Abbas
Movafagh, Abolfazl
Mehdizadeh, Mahshid
Akbari, Mohammad Taghi
Sayad, Arezou
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The Hodgkin’s lymphoma disease (HD) is a common malignant neoplasm with germinal centre B-cell origin.
It has been suggested that the HLA class I and class II regions have susceptibility effects on HD.
In different ethnic groups, different HLA class I and class II alleles affect HD.
As a result, there is no consensus which of the different HLA alleles confers susceptibility to HD.
In this study, we aimed to ascertain the role of HLA class I and class II alleles in association with Hodgkin’s lymphoma in Iranian patients.
We performed a case-control genotyping study in 85 Iranian HD patients which were selected from the Bone Marrow Transplantation Department of Taleghani Hospital and 150 controls using the SSP-PCR.
Our results demonstrated that the HLA-A*68, HLA-B*51, and HLA-DRB1*15 alleles were significantly more frequent in HD patients in comparison to controls (P=0.026; OR = 6.188, P=0.00008; OR = 2.86, P=0.00006; OR = 5.315, resp.) and they have significant susceptibility effects on HD in Iranian population.
There are reports of other populations with regard to consistency and inconsistency to our results.
Further studies with large sample size or the meta-analysis are needed to explain the exact associations of HLA gene with HD.
American Psychological Association (APA)
Sayad, Arezou& Akbari, Mohammad Taghi& Mehdizadeh, Mahshid& Movafagh, Abolfazl& Hajifathali, Abbas. 2014. The Association of HLA-Class I and Class II with Hodgkin’s Lymphoma in Iranian Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455765
Modern Language Association (MLA)
Sayad, Arezou…[et al.]. The Association of HLA-Class I and Class II with Hodgkin’s Lymphoma in Iranian Patients. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-455765
American Medical Association (AMA)
Sayad, Arezou& Akbari, Mohammad Taghi& Mehdizadeh, Mahshid& Movafagh, Abolfazl& Hajifathali, Abbas. The Association of HLA-Class I and Class II with Hodgkin’s Lymphoma in Iranian Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455765