Lipoxin A4 Preconditioning and Postconditioning Protect Myocardial IschemiaReperfusion Injury in Rats
Joint Authors
Qiu, Huixian
Xia, Jie
Shao, Lan
Zhao, Qifeng
Wu, Guowei
Hu, Xingti
Du, Jie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study aims to investigate the pre- and postconditioning effects of lipoxin A4 (LXA4) on myocardial damage caused by ischemia/reperfusion (I/R) injury.
Seventy-two rats were divided into 6 groups: sham groups (C1 and C2), I/R groups (I/R1 and I/R2), and I/R plus LXA4 preconditioning and postconditioning groups (LX1 and LX2).
The serum levels of IL-1β, IL-6, IL-8, IL-10, TNF-α, and cardiac troponin I (cTnI) were measured.
The content and the activity of Na+-K+-ATPase as well as the superoxide dismutase (SOD), and malondialdehyde (MDA) levels were determined.
Along with the examination of myocardium ultrastructure and ventricular arrhythmia scores (VAS), connexin 43 (Cx43) expression were also detected.
Lower levels of IL-1β, IL-6, IL-8, TNF-α, cTnI, MDA content, and VAS and higher levels of IL-10, SOD activity, Na+-K+-ATPase content and activity, and Cx43 expression appeared in LX groups than I/R groups.
Besides, H&E staining, TEM examination as well as analysis of gene, and protein confirmed that LXA4 preconditioning was more effective than postconditioning in preventing arrhythmogenesis via the upregulation of Cx43.
That is, LXA4 postconditioning had better protective effect on Na+-K+-ATPase and myocardial ultrastructure.
American Psychological Association (APA)
Zhao, Qifeng& Shao, Lan& Hu, Xingti& Wu, Guowei& Du, Jie& Xia, Jie…[et al.]. 2013. Lipoxin A4 Preconditioning and Postconditioning Protect Myocardial IschemiaReperfusion Injury in Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455779
Modern Language Association (MLA)
Zhao, Qifeng…[et al.]. Lipoxin A4 Preconditioning and Postconditioning Protect Myocardial IschemiaReperfusion Injury in Rats. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-455779
American Medical Association (AMA)
Zhao, Qifeng& Shao, Lan& Hu, Xingti& Wu, Guowei& Du, Jie& Xia, Jie…[et al.]. Lipoxin A4 Preconditioning and Postconditioning Protect Myocardial IschemiaReperfusion Injury in Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455779