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Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
It was assumed that resolution of hypercortisolism in Cushing syndrome (CS) was followed by normalization of morbidity; however, in the last decade evidence is accumulating that patients with cured CS still have increased morbidity and mortality after the biochemical control of hypercortisolism.
Patients with CS have an increased cardiovascular and metabolic risk and persistent accumulation of central fat, with an unfavorable adipokine profile, not only during the active phase of the disease but also long after biochemical remission.
Clinical management should be particularly careful in identifying global cardiovascular risk, as a primary goal during the followup of these patients, aimed at improving global vascular morbidity.
Moreover bone mass is reduced not only due to the endogenous hypercortisolism but also due to duration and dose of exogenous glucocorticoid (GC) replacement therapy after surgery.
Thus, therapy in operated patients with inhibition of the hypothalamic-pituitary-adrenal axis should be reduced to the lowest dose and duration possible.
Specific treatments should be considered in patients with decreased bone mass, aimed at reducing the increased fracture incidence.
Finally, cognitive and health related quality of life impairments, described in active disease, are still abnormal after endocrine cure.
Thus, residual morbidity persists in cured CS, suggesting irreversibility of GC-induced phenomena, typical of chronic hypercortisolism.
American Psychological Association (APA)
Resmini, Eugenia. 2014. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455784
Modern Language Association (MLA)
Resmini, Eugenia. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-455784
American Medical Association (AMA)
Resmini, Eugenia. Persistent Comorbidities in Cushing’s Syndrome after Endocrine Cure. Advances in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-455784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455784