CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features
Joint Authors
Chou, Ying-Erh
Lee, Hsiang-Lin
Chiou, Hui-Ling
Chen, Tzy-Yen
Yang, Shun-Fa
Hsieh, Ming-Ju
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan.
CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis.
We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to HCC susceptibility and clinicopathological characteristics.
Six SNPs of CD44 were analyzed using a real-time polymerase chain reaction (PCR) in 203 patients with HCC and in 561 cancer-free controls.
We determined that the individuals carrying at least one G allele at CD44 rs187115 has higher risk of developing HCC than did wild-type (AA) carriers.
We further observed that the CD44 rs187115 polymorphisms with at least one G allele had a higher frequency of distribution in nonsmoking stage III/IV HCC patients, compared with wild-type carriers.
Our results suggested that patients with CD44 rs187115 variant genotypes (AG+GG) were associated with a higher risk of HCC development and that these patients might possess chemoresistance, causing more likely progression to late-stage HCC than wild-type carriers without the overexpression of CD44 induced by heavy smoking.
CD44 rs187115 might be involved in CD44 isoform expression of p53 stress response in HCC and provide a marker for predicting worst-case prognosis of HCC.
American Psychological Association (APA)
Chou, Ying-Erh& Hsieh, Ming-Ju& Chiou, Hui-Ling& Lee, Hsiang-Lin& Yang, Shun-Fa& Chen, Tzy-Yen. 2014. CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455790
Modern Language Association (MLA)
Chou, Ying-Erh…[et al.]. CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-455790
American Medical Association (AMA)
Chou, Ying-Erh& Hsieh, Ming-Ju& Chiou, Hui-Ling& Lee, Hsiang-Lin& Yang, Shun-Fa& Chen, Tzy-Yen. CD44 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility and Clinicopathologic Features. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455790