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Low Levels of Serum Paraoxonase Activities are Characteristic of Metabolic Syndrome and May Influence the Metabolic-Syndrome-Related Risk of Coronary Artery Disease
Joint Authors
Trabetti, Elisabetta
Pignatti, Pier Franco
Friso, Simonetta
Micaglio, Roberta
Olivieri, Oliviero
Martinelli, Nicola
Pizzolo, Francesca
Grison, Elisa
Girelli, Domenico
Guarini, Patrizia
Consoli, Letizia
Corrocher, Roberto
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Low concentrations of plasma high-density lipoprotein (HDLs) are characteristic in metabolic syndrome (MS).
The antioxidant ability of HDLs is, at least in part, attributable to pleiotropic serum paraoxonase (PON1).
Different PON1 activities have been assessed in 293 subjects with (n=88) or without MS (n=205) and with (n=195) or without (n=98) angiographically proven coronary artery disease (CAD).
MS subjects had low PON1 activities, with a progressively decreasing trend by increasing the number of MS abnormalities.
The activity versus 7-O-diethyl phosphoryl,3-cyano,4-methyl,7-hydroxycoumarin (DEPCyMC), which is considered a surrogate marker of PON1 concentration, showed the most significant association with MS, independently of both HDL and apolipoprotein A-I levels.
Subjects with MS and low DEPCyMCase activity had the highest CAD risk (OR 4.34 with 95% CI 1.44–13.10), while no significant increase of risk was found among those with MS but high DEPCyMCase activity (OR 1.45 with 95% CI 0.47–4.46).
Our results suggest that low PON1 concentrations are typical in MS and may modulate the MS-related risk of CAD.
American Psychological Association (APA)
Martinelli, Nicola& Micaglio, Roberta& Consoli, Letizia& Guarini, Patrizia& Grison, Elisa& Pizzolo, Francesca…[et al.]. 2011. Low Levels of Serum Paraoxonase Activities are Characteristic of Metabolic Syndrome and May Influence the Metabolic-Syndrome-Related Risk of Coronary Artery Disease. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-455796
Modern Language Association (MLA)
Martinelli, Nicola…[et al.]. Low Levels of Serum Paraoxonase Activities are Characteristic of Metabolic Syndrome and May Influence the Metabolic-Syndrome-Related Risk of Coronary Artery Disease. Experimental Diabetes Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-455796
American Medical Association (AMA)
Martinelli, Nicola& Micaglio, Roberta& Consoli, Letizia& Guarini, Patrizia& Grison, Elisa& Pizzolo, Francesca…[et al.]. Low Levels of Serum Paraoxonase Activities are Characteristic of Metabolic Syndrome and May Influence the Metabolic-Syndrome-Related Risk of Coronary Artery Disease. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-455796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455796