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Imaging Multidimensional Therapeutically Relevant Circadian Relationships
Joint Authors
Singletary, Jamil
Wang, Song
Vishnoi, Shobhit
Yang, Xiaoming
Hrushesky, William J. M.
Du-Quiton, Jovelyn
Wood, Patricia A.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways.
This temporal coordination occurs within both cancerous and noncancerous proliferating tissues.
The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers.
Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies.
The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations.
We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day.
The systems and methods used to create these depictions are provided, as well as three example supplementary movies.
American Psychological Association (APA)
Singletary, Jamil& Wood, Patricia A.& Du-Quiton, Jovelyn& Wang, Song& Yang, Xiaoming& Vishnoi, Shobhit…[et al.]. 2009. Imaging Multidimensional Therapeutically Relevant Circadian Relationships. International Journal of Biomedical Imaging،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-455800
Modern Language Association (MLA)
Singletary, Jamil…[et al.]. Imaging Multidimensional Therapeutically Relevant Circadian Relationships. International Journal of Biomedical Imaging No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-455800
American Medical Association (AMA)
Singletary, Jamil& Wood, Patricia A.& Du-Quiton, Jovelyn& Wang, Song& Yang, Xiaoming& Vishnoi, Shobhit…[et al.]. Imaging Multidimensional Therapeutically Relevant Circadian Relationships. International Journal of Biomedical Imaging. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-455800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455800