CeruloplasminTransferrin Ratio Changes in Alzheimer's Disease
Joint Authors
Fabrizio, Vernieri
Lupoi, Domenico
Rossini, Paolo Maria
Squitti, Rosanna
Salustri, Carlo
Ventriglia, Mariacarla
Cassetta, Emanuele
Siotto, Mariacristina
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD.
In the present study, we have instead looked at systemic variations of markers of iron metabolism.
We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation and the ceruloplasmin to transferrin ratio (Cp/Tf).
Cp/Tf and transferrin saturation increased in AD patients.
Cp/Tf ratios also correlated positively with peroxide levels and negatively with serum iron concentrations.
Elevated values of ceruloplasmin, peroxides, and Cp/Tf inversely correlated with MMSE scores.
Isolated medial temporal lobe atrophy positively correlated with Cp/Tf and negatively with serum iron.
All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations.
American Psychological Association (APA)
Squitti, Rosanna& Salustri, Carlo& Siotto, Mariacristina& Ventriglia, Mariacarla& Fabrizio, Vernieri& Lupoi, Domenico…[et al.]. 2010. CeruloplasminTransferrin Ratio Changes in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455806
Modern Language Association (MLA)
Squitti, Rosanna…[et al.]. CeruloplasminTransferrin Ratio Changes in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-455806
American Medical Association (AMA)
Squitti, Rosanna& Salustri, Carlo& Siotto, Mariacristina& Ventriglia, Mariacarla& Fabrizio, Vernieri& Lupoi, Domenico…[et al.]. CeruloplasminTransferrin Ratio Changes in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455806