Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
Joint Authors
Hogg, D.
Wunder, Jay S.
O’Sullivan, B.
al-Hussaini, H.
Hopyan, S.
Blackstein, Martin E.
Gupta, A. A.
Griffin, Anthony M.
Hodgson, D.
Ferguson, Peter C.
Catton, Charles
Chung, P. W.
Kandel, Rita A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
There remains controversy on the routine use of chemotherapy in localized SS.
Methods.
The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed.
Results.
Median age for AP and PP was 37.6 (range 15–76) and 14 (range 0.4–18) years, respectively.
65 (64%) patients had large tumours (>5 cm).
All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins.
72 (82.8%) AP and 8 (53%) PP received radiotherapy.
Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP.
10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively.
5-year EFS and OS was 69.3±4.8% and 80.3±4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without.
Conclusions.
Patients with localized SS have a good chance of cure with surgery and RT.
Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive.
American Psychological Association (APA)
al-Hussaini, H.& Hogg, D.& Blackstein, Martin E.& O’Sullivan, B.& Catton, Charles& Chung, P. W.…[et al.]. 2011. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Sarcoma،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455829
Modern Language Association (MLA)
al-Hussaini, H.…[et al.]. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Sarcoma No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-455829
American Medical Association (AMA)
al-Hussaini, H.& Hogg, D.& Blackstein, Martin E.& O’Sullivan, B.& Catton, Charles& Chung, P. W.…[et al.]. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455829