Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells
Joint Authors
Ma, Jin Yeul
Yim, Nam-Hui
Ma, Choong Je
Kim, Aeyung
Cho, Won-Kyung
Jung, Young Pil
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oyaksungisan (OY) is a traditional herbal formula broadly used to treat beriberi, vomiting, diarrhea, and circulatory disturbance in Asian countries from ancient times.
The effect of OY on cancer, however, was not reported until now.
In this study, we have demonstrated that OY inhibits cell proliferation and induces cell death via modulating the autophagy on human colon cancer cells.
In HCT116 cells, OY increased the ratio of LC3-II/LC3-I, a marker of autophagy, and treatment with 3-MA, an inhibitor of autophagy, and considerably reduced the formation of autophagosomes.
In addition, OY regulated mitogen-activated protein kinase (MAPK) cascades; especially, JNK activation was closely related with autophagy effect by OY in HCT116 cells.
Our results indicate that autophagy induction is responsible for the antiproliferative effect by OY, despite the weak apoptosis induction in HCT116 cells.
In conclusion, OY might have a potential to be developed as an herbal anticancer remedy.
American Psychological Association (APA)
Yim, Nam-Hui& Jung, Young Pil& Kim, Aeyung& Ma, Choong Je& Cho, Won-Kyung& Ma, Jin Yeul. 2013. Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-455842
Modern Language Association (MLA)
Yim, Nam-Hui…[et al.]. Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-455842
American Medical Association (AMA)
Yim, Nam-Hui& Jung, Young Pil& Kim, Aeyung& Ma, Choong Je& Cho, Won-Kyung& Ma, Jin Yeul. Oyaksungisan, a Traditional Herbal Formula, Inhibits Cell Proliferation by Induction of Autophagy via JNK Activation in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-455842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455842